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Study, Research M4A, sufferers were randomly designated in a 1:4 ratio to receive placebo or dupilumab at a dose of 75 mg , 150 mg , or 300 mg , with all study drugs administered once a week subcutaneously. In the multinational research, Study M4B, patients were randomly assigned in a 1:3 ratio to get placebo or dupilumab at a dose of 150 mg or 300 mg , with all study drugs administered subcutaneously once weekly. Both studies were made to assess safety as the primary end point. Prespecified exploratory efficacy end factors included the proportion of individuals who got an investigator’s global assessment rating of 0 or 1 , the %age reduction in the affected body-surface area, the rating on the Eczema Area and Intensity Index ,9,10 the score on the 5-D pruritus scale ,11 the rating on the pruritus numerical-rating scale ,12 and degrees of biomarkers .