AAQ chemical restores vision in blind mice temporarily A group of University of California.

Eight years ago, Kramer, Trauner, a former UC Berkeley chemist at the University of Munich now, and their colleagues developed an optogenetic strategy to chemically alter potassium ion channels in blind neurons so that a photoswitch could latch on. Potassium channels normally open to turn a cell off, but with the attached photoswitch, they were opened when hit by ultraviolet light and closed when strike by green light, thereby activating and deactivating the neurons.Treatment with peptide N-glycosidase F caused a considerable shift in the flexibility of this antigen, to approximately 145 kD, indicating that it is glycosylated heavily. All serum samples which were reactive with the native 185-kD band also recognized the smaller initially, deglycosylated band . Both the native and N-deglycosylated types of the antigen could possibly be bound and substantially enriched through absorption by wheat-germ agglutinin .

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