Timothy J more . Whelan, B.M., B.Ch., Ivo A. Olivotto, M.D., Wendy R. Parulekar, M.D., Ida Ackerman, M.D., Boon H. Chua, M.B., B.S., Ph.D., Abdenour Nabid, M.D., Katherine A. Vallis, M.B., B.S., Ph.D., Julia R. White colored, M.D., Pierre Rousseau, M.D., Andre Fortin, M.D., Lori J. Pierce, M.D., Lee Manchul, M.D., Susan Chafe, M.D., Maureen C. Nolan, M.D., Peter Craighead, M.D., Julie Bowen, M.D., David R. McCready, M.D., Kathleen I. Pritchard, M.D., Karen Gelmon, M.D., Yvonne Murray, B.Sc., Judy-Anne W. Chapman, Ph.D., Bingshu E. Chen, Ph.D., and Mark N. Levine, M.D. For the MA.20 Study Investigators: Regional Nodal Irradiation in Early-Stage Breast Cancer Many women with early-stage breast cancer undergo breast-conserving surgery accompanied by whole-breast irradiation, which reduces the rate of regional recurrence.1-3 Radiotherapy to the chest wall structure and regional lymph nodes, termed regional nodal irradiation, which is often used following mastectomy in women with node-positive breast malignancy who are treated with adjuvant systemic therapy, reduces locoregional and distant recurrence and improves general survival.4-6 An unanswered issue is whether the addition of regional nodal irradiation to whole-breast irradiation after breast-conserving surgery gets the same effect.
To comprehend cell division in a comprehensive way, the MitoCheck consortium of European researchers will systematically hunt for all genes that are necessary for division and check the items of the genes to observe how they are regulated by mitotic kinases. Another MitoCheck partner, the Max-Planck Institute of Cell Genetics and Biology in Dresden provides a vast library of these molecules. About 20,000 genes will be suppressed one-by-one and EMBL researchers will make movies of the cells going through division, using sophisticated microscopes developed by Rainer Pepperkok, Jan Ellenberg and Leica Microsystems.