Medications can be an important part of treatment for some types of substance abuse, especially when coupled with counseling and additional behavioral therapies. There exists a significant amount of evidence that individuals with addictions and coexisting mental disorders must have both disorders treated in an integrated method. Treatment does not need to be voluntary to work. For example, motivation by companies or family can encourage people who have addictions to search out and continue treatment. This is thought to be the reason that physicians and nurses have some of the best recovery rates.Pedicone, Ph.D., Clifford A. Brass, M.D., Janice K. Albrecht, Ph.D., and Mark S. Sulkowski, M.D. For the IDEAL Study Team: Peginterferon Alfa-2b or Alfa-2a with Ribavirin for Treatment of Hepatitis C Infection Hepatitis C virus chronically infects approximately 180 million people worldwide1 and is a frequent reason behind liver disease, including liver failure and hepatocellular carcinoma.2 HCV treatment is recommended for persons at the best risk for progression of liver disease.3 On the basis of noncomparative studies demonstrating related safety and efficacy between your two treatments,4,5 consensus guidelines recommend the usage of either peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for the treating chronic hepatitis C.