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Model 1 is the foundation model with adjustment for age group, sex, scientific site, and baseline eGFR. Model 2 added socioeconomic variables . Model 3 added clinical risk factors . Model 4 added total 24-hour urinary protein excretion. Model 3 was chosen as the primary model because proteinuria may mediate the association between APOL1 and the progression of chronic kidney disease. Thus, the inclusion of proteinuria in model 4 may be an overadjustment. Outcomes AASK Study Population Table 1Table 1Baseline Characteristics of the 693 Sufferers in AASK, According to the Amount of APOL1 Variants. Summarizes the baseline characteristics of the 693 sufferers who were included in the current analysis.

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