When the researchers put their new sensor into living mammalian cells grown in the lab, they were able to test the effects of 160 different chemicals at once and see approved by the U.S.cals could turn on or off the PKA enzyme looking for green or blue glowing cells.
‘If we to find a new activity for a known drug, this may lead to a new use or a new way of thinking about this drug cause,’says Zhang to test to test the rest of the chemicals in the collection ,, their ability to interfere with the enzyme tested in this study. The search for a drug that can tame this enzyme could lead to new treatments for cardiovascular disease, diabetes, memory disorders and certain cancers.. Zhang says the ‘high-throughput ‘potential of the sensor may have wide-ranging applications, which is suitable for various chemicals will test testing chemicals for their ability, may interfere with other enzymes with respect to PKA a family a family than known kinases – that in in common diseases and a new class of drug targets.
Of the 160 chemicals tested, three caused cells to turn on the switch and two others caused cells to turn off the switch.The 160 chemicals tested are from the Johns Hopkins Clinical Compound Library, a collection of about 3,300 chemicals. Read More