Study Patients Our 8-week multicenter, randomized, double-blind, placebo-controlled trial was conducted at 51 centers in 17 countries from January 2009 through September 2010. Two eligibility criteria were an age group of at least 18 years and a verified diagnosis of ulcerative colitis for at least 3 months. The various other two eligibility requirements relate with the Mayo scoring system for assessment of ulcerative colitis activity ,21 a level composed of four subscores .Acid resistance is normally a valued trait for both supplements and human pathogens. The bacterium Acetobacter aceti makes acid-resistant enzymes in spades unusually, which could make the organism a supply for new enzyme items and new directions in protein chemistry. A. Aceti offers been utilized for millennia to create vinegar, at least since an indirect reference in the Aged Testament Book of Amounts to vinegar created from wine. However, not until lately did anybody study the unusual biochemical top features of the organism that let it survive and also thrive in extremely acidic conditions.